SCHEMBL8891093

SCHEMBL8891093

CS(=O)(=O)c1cccc(F)c1Cc1ccccc1C(=O)c1cnoc1C1CC1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 1/20 0.34
JAK2 O60674 3/20 0.33
JAK1 P23458 3/20 0.33
TYK2 P29597 3/20 0.33
DPP4 P27487 1/20 0.33
LMNA P02545 2/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
F10 P00742 1/20 0.32
DHODH Q02127 1/20 0.31
CACNA1B Q00975 2/20 0.31
SLC9A1 P19634 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8890935 0.89 DHODH (0.36) LMNAKDM4EALDH1A1HPGDHSD17B10
SCHEMBL8891693 0.89 SLC9A1 (0.37) NR3C1F10DHODHCACNA1BSLC9A1
SCHEMBL8890546 0.89 NR1H4 (0.35) NR3C1JAK2JAK1TYK2LMNA
SCHEMBL8891637 0.87 LMNA (0.34) NR3C1JAK2JAK1TYK2LMNA
SCHEMBL8890477 0.87 NR3C1 (0.38) NR3C1JAK2JAK1TYK2LMNA
SCHEMBL8889540 0.87 DHODH (0.32) ALDH1A1HSD17B10DHODHCYP1A2CYP3A4
SCHEMBL8889420 0.84 MEN1 (0.38) JAK2JAK1TYK2LMNAKDM4E
SCHEMBL8890973 0.84 NAAA (0.32) NR3C1JAK2JAK1TYK2LMNA
SCHEMBL8891827 0.83 LMNA (0.36) NR3C1JAK2JAK1TYK2LMNA
SCHEMBL8890152 0.83 LMNA (0.36) NR3C1JAK2JAK1TYK2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997028136-A1 BENZOYLISOXAZOLES AND 2-CYANO-1,3-DIONE DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1997-08-07 WO disclosed