Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 13/20 | 0.48 |
| ▸ | RORC | P51449 | 7/20 | 0.48 |
| ▸ | THRA | P10827 | 8/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255682 | 0.87 | P2RX3 (0.39) | THRBRORCTHRAP2RX3P2RX2 | |
| SCHEMBL7256720 | 0.84 | THRB (0.38) | THRBRORCTHRAP2RX3P2RX2 | |
| SCHEMBL8891859 | 0.83 | THRB (0.44) | THRBRORCTHRA | |
| SCHEMBL6818059 | 0.81 | RORC (0.70) | THRBRORCTHRAP2RX3P2RX2 | |
| SCHEMBL22959351 | 0.77 | THRB (0.48) | THRBRORCTHRA | |
| SCHEMBL8890840 | 0.76 | THRB (0.46) | THRBRORCTHRA | |
| SCHEMBL14383404 | 0.73 | THRB (0.66) | THRBTHRA | |
| SCHEMBL17782690 | 0.72 | MEN1 (0.41) | THRB | |
| SCHEMBL7255718 | 0.70 | KIF11 (0.41) | THRBRORCTHRA | |
| SCHEMBL22959261 | 0.70 | THRB (0.70) | THRBRORCTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654468-A | ANTILIPID, ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5569674-A | ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-10-29 | — | — | US | disclosed |
| US-5401772-A | Anticholesterol agents with aromatic amines | CIBA-GEIGY CORPORATION (US) | 1995-03-28 | — | — | US | disclosed |