Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241582 | 0.98 | LMNA (0.37) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL2826604 | 0.98 | LMNA (0.37) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL221185 | 0.98 | LMNA (0.37) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL9862355 | 0.98 | LMNA (0.37) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL9862354 | 0.98 | LMNA (0.37) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| Alcohol SCHEMBL11674015 | 0.90 | ALDH1A1 (0.33) | ALDH1A1LMNATHRBALOX15MAPK1 | |
| SCHEMBL1868393 | 0.76 | — | — | |
| SCHEMBL11504897 | 0.73 | LMNA (0.32) | LMNAMAPK1 | |
| SCHEMBL13400151 | 0.72 | — | — | |
| SCHEMBL9053737 | 0.72 | LMNA (0.35) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108601755-B | Composition for preventing or treating myasthenia-related diseases comprising pinol hydrate | 韩国生命工学研究院 | 2021-08-10 | — | — | CN | claimed |
| US-9939747-B2 | Developing agent and method for producing the same | TOSHIBA TEC KABUSHIKI KAISHA (JP) | 2018-04-10 | — | — | US | claimed |
| US-20170038698-A1 | DEVELOPING AGENT AND METHOD FOR PRODUCING THE SAME | TOSHIBA TEC KABUSHIKI KAISHA (JP) | 2017-02-09 | — | — | US | claimed |
| EP-1902706-B1 | Stable pharmaceutical compositions of tetracyclines in solution, method for obtaining them and their uses | DIVASA FARMAVIC S A (ES) | 2016-11-02 | — | — | EP | claimed |
| EP-1902706-A1 | Stable pharmaceutical compositions of tetracyclines in solution, method for obtaining them and their uses | Divasa-Farmavic, S.A. (ES) | 2008-03-26 | — | — | EP | claimed |
| EP-0251905-B1 | Esters of alginic acid | FIDIA SPA (IT) | 1994-11-02 | — | — | EP | claimed |
| EP-0609968-A2 | Compositions comprising partial esters of alginic acid | FIDIA S.p.A. (IT) | 1994-08-10 | — | — | EP | claimed |
| US-5173113-A | Low-solvent or nonsolvent, quick drying | TOPEZ COMPANY (IO) | 1992-12-22 | — | — | US | claimed |
| EP-0503897-A1 | Composition for ink vehicles and protective coatings | TOPEZ COMPANY (TC) | 1992-09-16 | — | — | EP | claimed |
| CN-87104499-A | Novel alginic acid esters | — | 1988-04-06 | — | — | CN | claimed |
| EP-0251905-A2 | Esters of alginic acid | FIDIA S.p.A. (IT) | 1988-01-07 | — | — | EP | claimed |
| CN-115038471-B | Compositions for clinical complications associated with devices implanted in the urinary tract | 德维护理有限公司 | 2024-05-14 | — | — | CN | disclosed |
| WO-2023085225-A1 | METHOD FOR MANUFACTURING RECYCLED RESIN COMPOSITION | 住友化学株式会社 | 2023-05-19 | — | — | WO | disclosed |
| US-11555099-B2 | Method for producing colorable material | TOSHIBA TEC KABUSHIKI KAISHA (JP) | 2023-01-17 | — | — | US | disclosed |
| CN-115038471-A | Compositions for clinical complications associated with devices implanted in the urinary tract | 德维护理有限公司 | 2022-09-09 | — | — | CN | disclosed |
| WO-1989010941-A1 | CROSS-LINKED CARBOXY POLYSACCHARIDES | FIDIA S.P.A. (IT) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341745-A1 | Crosslinked carboxy polysaccharides | FIDIA S.p.A. (IT) | 1989-11-15 | — | — | EP | disclosed |
| US-4851521-A | Esters of hyaluronic acid | FIDIA, S.P.A. (IT) | 1989-07-25 | — | — | US | disclosed |
| EP-0216453-A2 | Esters of hyaluronic acid and their salts. | FIDIA S.p.A. (IT) | 1987-04-01 | — | — | EP | disclosed |
| US-4639469-A | RESPIRATORY ANALEPTIC | CORVI MORA CAMILLO (IT) | 1987-01-27 | — | — | US | disclosed |