Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Chloroform. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL28063298 | 1.00 | LMNA (0.50) | LMNATSHRALDH1A1CYP3A4ALOX15 | |
| Chloroform SCHEMBL28040546 | 1.00 | — | — | |
| Chloroform SCHEMBL27706310 | 1.00 | LMNA (0.50) | LMNATSHRALDH1A1CYP3A4ALOX15 | |
| Chloroform SCHEMBL25447 | 1.00 | — | — | |
| Chloroform SCHEMBL9617984 | 1.00 | LMNA (0.50) | LMNATSHRALDH1A1CYP3A4ALOX15 | |
| Chloroform SCHEMBL28856156 | 0.94 | — | — | |
| Chloroform SCHEMBL241751 | 0.94 | — | — | |
| Chloroform SCHEMBL4395340 | 0.94 | LMNA (0.44) | LMNATSHRALDH1A1 | |
| Chloroform SCHEMBL237266 | 0.94 | — | — | |
| Chloroform SCHEMBL9525441 | 0.94 | LMNA (0.57) | LMNATSHRALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101456841-B | Amide derivative and medicine | NIPPON SHINYAKU CO LTD | 2012-01-25 | — | — | CN | disclosed |
| CN-101690752-A | Quality control method of medicine composition | GUANGXI LINGFENG PHARMACEUTICA | 2010-04-07 | — | — | CN | disclosed |
| CN-100526298-C | Amide derivative and pharmaceutical | NIPPON SHINYAKU CO LTD (JP) | 2009-08-12 | — | — | CN | disclosed |
| CN-101456841-A | Amide derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 2009-06-17 | — | — | CN | disclosed |
| CN-1898208-A | Amide derivative and pharmaceutical | NIPPON SHINYAKU CO LTD (JP) | 2007-01-17 | — | — | CN | disclosed |
| EP-0303697-B1 | DERIVATIVES OF PHYSIOLOGICALLY ACTIVE SUBSTANCE K-252 | KYOWA HAKKO KOGYO KK (JP) | 1997-10-01 | — | — | EP | disclosed |
| EP-0261004-B1 | IMIDAZOLE DERIVATIVES AND THEIR SALTS, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-05-26 | — | — | EP | disclosed |
| EP-0140327-B1 | BIS-DIOXOPIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, ANTITUMOR AGENTS COMPRISING THEM AND COMPOSITIONS CONTAINING THEM | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-05-23 | — | — | EP | disclosed |
| US-4923986-A | EPOXYTRIAZADIBENZO/A,G/CYCLOOCTA/C,D,E/-TRINDENONE, KINASE INHIBITORS, ANTITUMOR AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-05-08 | — | — | US | disclosed |
| US-4810828-A | ANTIARTHRITIC, PSORIASIS | ROUSSEL UCLAF (FR) | 1989-03-07 | — | — | US | disclosed |
| EP-0303697-A1 | DERIVATIVES OF PHYSIOLOGICALLY ACTIVE SUBSTANCE K-252 | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-02-22 | — | — | EP | disclosed |
| EP-0261004-A2 | Imidazole derivatives and their salts, process for their preparation, their use as medicines, and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-03-23 | — | — | EP | disclosed |
| EP-0089055-B1 | DEAZAPURINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1987-06-03 | — | — | EP | disclosed |
| US-4650799-A | Bis-dioxopiperazine derivatives, process for their preparation, antitumor agents comprising them and compositions containing them | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-03-17 | — | — | US | disclosed |
| US-4571423-A | Substituted 5-aminomethyl-2-acylaminopyrrolo[2,3-d]pyrimidin-4-ones | TAKEDA CHEMICAL INDUSTRIES LTD. (JP) | 1986-02-18 | — | — | US | disclosed |
| EP-0089055-A2 | Deazapurine derivatives | Takeda Chemical Industries, Ltd. (JP) | 1983-09-21 | — | — | EP | disclosed |