SCHEMBL8908948

SCHEMBL8908948

Fc1ccc(Nc2nc(NCc3ccc(Cl)nc3)nc(N/N=C/c3cccc(OC(F)(F)C(F)F)c3)n2)cc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.39
PRKCA P17252 3/20 0.38
STK17A Q9UEE5 2/20 0.36
STK17B O94768 1/20 0.36
DDX3X O00571 1/20 0.36
MAPT P10636 4/20 0.34
ALDH1A1 P00352 3/20 0.34
NPSR1 Q6W5P4 3/20 0.34
TDP1 Q9NUW8 2/20 0.34
GAA P10253 1/20 0.34
MAP2K7 O14733 1/20 0.34
KCNH3 Q9ULD8 1/20 0.34
PTK2 Q05397 1/20 0.34
ABL1 P00519 3/20 0.34
BCR P11274 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CCNB2 O95067 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8908985 0.94 SLC2A1 (0.41) SLC2A1STK17ASTK17BDDX3XMAPT
SCHEMBL8909707 0.92 DDX3X (0.39) SLC2A1PRKCASTK17ASTK17BDDX3X
SCHEMBL8908953 0.91 KCNH3 (0.44) SLC2A1STK17ASTK17BDDX3XMAPT
SCHEMBL8908807 0.89 SLC2A1 (0.44) SLC2A1STK17ASTK17BDDX3XMAPT
SCHEMBL8908847 0.88 SLC2A1 (0.43) SLC2A1STK17ASTK17BDDX3XMAPT
SCHEMBL8909751 0.87 SLC2A1 (0.43) SLC2A1STK17ASTK17BDDX3XMAPT
SCHEMBL8909066 0.87 PRKCA (0.48) SLC2A1PRKCADDX3XMAPTALDH1A1
SCHEMBL8910086 0.87 MAPT (0.46) SLC2A1STK17ASTK17BDDX3XMAPT
SCHEMBL13883263 0.87 SLC2A1 (0.42) SLC2A1STK17ASTK17BDDX3XMAPT
SCHEMBL8909095 0.85 CA12 (0.42) SLC2A1PRKCADDX3XMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ SLC2A1 4129/4885PRKCA 3642/4885STK17A 2330/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ SLC2A1 4129/4885PRKCA 3642/4885STK17A 2330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.