Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.41 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909154 | 0.92 | REN (0.41) | RENPYGLFLT3P2RX1 | |
| SCHEMBL8909458 | 0.91 | PYGL (0.36) | RENPYGLP2RX1ARKDM4E | |
| SCHEMBL8910700 | 0.90 | REN (0.40) | RENPYGLP2RX1KDM4EHSD17B10 | |
| SCHEMBL8910252 | 0.89 | KDM4E (0.39) | RENPYGLFLT3MEN1KMT2A | |
| SCHEMBL8910197 | 0.82 | REN (0.36) | RENMLLT1PYGLSMYD3P2RX1 | |
| SCHEMBL9800603 | 0.79 | REN (0.59) | RENMLLT1PYGLSMYD3P2RX1 | |
| SCHEMBL8909363 | 0.78 | P2RX1 (0.52) | RENP2RX1 | |
| SCHEMBL8910552 | 0.75 | REN (0.36) | RENP2RX1 | |
| SCHEMBL8909424 | 0.74 | SIRT2 (0.34) | RENPYGLP2RX1 | |
| SCHEMBL8908848 | 0.74 | F2R (0.37) | RENP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |