Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908407 | 0.80 | ALDH1A1 (0.39) | HTR2CHTR2AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8908933 | 0.76 | HTR2C (0.40) | HTR2CHTR2AALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8908855 | 0.75 | CYP1A2 (0.44) | ALDH1A1MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL8908279 | 0.73 | RAB9A (0.46) | HTR2CDRD2DRD3HTR2AALDH1A1 | |
| SCHEMBL8908448 | 0.73 | ALDH1A1 (0.43) | ALDH1A1CYP3A4CYP2D6CYP2C19POLB | |
| SCHEMBL11772030 | 0.69 | DRD2 (0.55) | DRD2DRD3ALDH1A1HTR3EHTR3B | |
| SCHEMBL8189587 | 0.67 | ALDH1A1 (0.63) | DRD2DRD3ALDH1A1HTR1AADRA1D | |
| SCHEMBL6635193 | 0.66 | KDM4E (0.62) | DRD2DRD3ALDH1A1HTR1AADRA1D | |
| SCHEMBL27612189 | 0.66 | ALDH1A1 (0.76) | HTR2CALDH1A1MEN1CYP3A4KMT2A | |
| SCHEMBL3556792 | 0.65 | DRD2 (0.68) | DRD2DRD3ALDH1A1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |