Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | RRM1 | P23921 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908407 | 0.84 | ALDH1A1 (0.39) | ALDH1A1POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8908933 | 0.80 | HTR2C (0.40) | ALDH1A1POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8908855 | 0.79 | CYP1A2 (0.44) | ALDH1A1POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8908279 | 0.76 | RAB9A (0.46) | ALDH1A1POLBCYP2D6GAASMN1; SMN2 | |
| SCHEMBL8909181 | 0.73 | HTR2C (0.49) | ALDH1A1POLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10863210 | 0.68 | HTR2A (0.52) | ALDH1A1POLBCYP3A4HTTLMNA | |
| SCHEMBL8907689 | 0.67 | SERPINE1 (0.36) | ALDH1A1POLBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4248218 | 0.66 | GAA (0.43) | ALDH1A1POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11117063 | 0.64 | LMNA (0.44) | ALDH1A1POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6171285 | 0.64 | GAA (0.63) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |
| US-5646146-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-07-08 | — | — | US | claimed |