SCHEMBL8913140

SCHEMBL8913140

CC(=O)OCCN(CCOC(C)=O)C(=O)c1c(F)ccc(N)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 3/20 0.36
TDP1 Q9NUW8 1/20 0.31
PHLPP2 Q6ZVD8 1/20 0.30
KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8914155 0.81 AR (0.37) MLYCDTDP1KCNH2
SCHEMBL31146135 0.69 THRB (0.35)
SCHEMBL9031800 0.64 RAD52 (0.40) TDP1
SCHEMBL15971303 0.64 KDM4E (0.40) TDP1
SCHEMBL8915526 0.62 GAA (0.40)
SCHEMBL27758313 0.61 MET (0.43) TDP1
SCHEMBL8772047 0.61 ICMT (0.32)
SCHEMBL10433181 0.61 ALDH1A1 (0.41)
SCHEMBL2746368 0.61 PDE3B (0.42)
SCHEMBL31146024 0.61 ALDH1A1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5686492-A NMR DIAGNOSTIC AGENTS SCHERING AKTIENGESELLSCHAFT (DE) 1997-11-11 US disclosed