Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | PRKCG | P05129 | 2/20 | 0.49 |
| ▸ | PRKCB | P05771 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | PRKCA | P17252 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | PRKACG | P22612 | 2/20 | 0.49 |
| ▸ | PRKACB | P22694 | 2/20 | 0.49 |
| ▸ | PRKCH | P24723 | 2/20 | 0.49 |
| ▸ | PRKCI | P41743 | 2/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912773 | 0.85 | PRKD3 (0.54) | P2RX7PRKD3PRKCGPRKCBCYP3A4 | |
| SCHEMBL8914454 | 0.84 | P2RX7 (0.51) | P2RX7PRKD3PRKCGPRKCBCYP3A4 | |
| SCHEMBL8913820 | 0.82 | PRKD3 (0.53) | P2RX7PRKD3PRKCGPRKCBCYP3A4 | |
| SCHEMBL8913773 | 0.82 | CTSL (0.48) | CYP3A4KDM4ECYP1A2CYP2C19MEN1 | |
| SCHEMBL8915081 | 0.80 | MMP2 (0.56) | MMP1MMP2MMP9MAPT | |
| SCHEMBL7120299 | 0.77 | P2RX7 (0.78) | P2RX7SMN1; SMN2HTTMAPT | |
| SCHEMBL9483456 | 0.77 | P2RX7 (0.78) | P2RX7SMN1; SMN2HTTMAPT | |
| SCHEMBL9484482 | 0.76 | P2RX7 (0.61) | P2RX7F2 | |
| SCHEMBL9484479 | 0.76 | P2RX7 (0.61) | P2RX7F2 | |
| SCHEMBL8913859 | 0.75 | CTSL (0.56) | MMP1MMP2MMP9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |