Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MYLK | Q15746 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914327 | 0.84 | CYP3A4 (0.48) | MAPK1CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL8913765 | 0.83 | F2 (0.49) | CTSLCTSBCTSSCTSKMAPK1 | |
| SCHEMBL8915081 | 0.83 | MMP2 (0.56) | CTSLCTSBCTSSCTSKMAPT | |
| SCHEMBL8914458 | 0.82 | P2RX7 (0.50) | CYP1A2CYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL8914340 | 0.81 | CYP3A4 (0.47) | MAPK1CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL8913859 | 0.78 | CTSL (0.56) | CTSLCTSBCTSSCTSKTP53 | |
| SCHEMBL8913470 | 0.70 | HTT (0.50) | CTSLCTSBCTSSCTSKMAPK1 | |
| SCHEMBL8914317 | 0.70 | CYP3A4 (0.46) | MAPK1CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL8914335 | 0.69 | ALDH1A1 (0.45) | MAPK1CYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL7475615 | 0.68 | NPY5R (0.53) | MEN1KMT2AUSP30HTTF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |