Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.44 |
| ▸ | GABRE | P78334 | 2/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912968 | 0.78 | GABRP (0.62) | GABRA5GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL4270536 | 0.76 | ACHE (0.52) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL583915 | 0.75 | AKR1B1 (0.60) | GABRA5GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL29108372 | 0.74 | GABRP (0.59) | GABRA5GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL16369830 | 0.73 | TSHR (0.50) | HSD17B10LMNATSHRKDM4EMAPT | |
| SCHEMBL22070781 | 0.72 | AKR1B1 (0.41) | GABRA5GABRB2AKR1B1GAAHSD17B10 | |
| SCHEMBL4596230 | 0.72 | GABRA5 (0.43) | GABRA5GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL477986 | 0.72 | CA2 (0.58) | AKR1B1THRBGAAHSD17B10LMNA | |
| SCHEMBL25309255 | 0.71 | THRB (0.47) | GABRA5GABRB2GABRPGABRDGABRA1 | |
| SCHEMBL15157078 | 0.71 | HTT (0.45) | GABRA5GABRB2GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693819-A | Process for the selective mono-ortho-hydroxyalkylation of 4-substituted pyridine derivatives | HOECHST ATKIENGESELLSCHAFT (DE) | 1997-12-02 | — | — | US | disclosed |
| EP-0533131-A1 | Process for selectively mono-ortho-hydroxy alkylation of 4-substituted pyridine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |