Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 8/20 | 0.51 |
| ▸ | HTR7 | P34969 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918424 | 0.94 | HTR1A (0.51) | SIGMAR1HTR1AHTR7DRD2DRD3 | |
| SCHEMBL8918497 | 0.88 | DRD4 (0.53) | HTR1AHTR7DRD2DRD3DRD4 | |
| SCHEMBL8917996 | 0.85 | SIGMAR1 (0.44) | SIGMAR1HTR1A | |
| SCHEMBL8919193 | 0.83 | TMEM97 (0.40) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL10393710 | 0.82 | HTR1A (0.67) | SIGMAR1HTR1AHTR7DRD2 | |
| SCHEMBL8919693 | 0.78 | POLB (0.46) | HTR1AHTR7 | |
| SCHEMBL8920270 | 0.78 | KMT2A (0.52) | HTR1AHTR7ADRA1DADRA1AADRA1B | |
| SCHEMBL8918622 | 0.77 | HRH3 (0.41) | SIGMAR1HTR1A | |
| SCHEMBL8918838 | 0.76 | DRD4 (0.51) | HTR1AHTR7DRD2DRD3DRD4 | |
| SCHEMBL8919139 | 0.75 | HRH3 (0.34) | SIGMAR1HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | claimed |
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |