Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918611 | 0.93 | SIGMAR1 (0.41) | SIGMAR1HTR1AEGFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL8919193 | 0.89 | TMEM97 (0.40) | SIGMAR1HTR1A | |
| SCHEMBL8917938 | 0.86 | PDE1B (0.43) | SIGMAR1POLBHTTKMT2ASMN1; SMN2 | |
| SCHEMBL8920545 | 0.85 | SIGMAR1 (0.52) | SIGMAR1HTR1A | |
| SCHEMBL8918622 | 0.83 | HRH3 (0.41) | SIGMAR1HTR1A | |
| SCHEMBL8919139 | 0.81 | HRH3 (0.34) | SIGMAR1KMT2AHTR1AHPGDALDH1A1 | |
| SCHEMBL9463688 | 0.78 | HTR1A (0.59) | SIGMAR1POLBHTTKMT2AHTR1A | |
| SCHEMBL8918424 | 0.77 | HTR1A (0.51) | SIGMAR1HTR1A | |
| SCHEMBL8628216 | 0.77 | PDE10A (0.35) | POLBHTTKMT2ASMN1; SMN2SRC | |
| SCHEMBL8629045 | 0.75 | ALDH1A1 (0.41) | SIGMAR1POLBHTTKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |