Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918497 | 0.87 | DRD4 (0.53) | DRD4DRD2HTR1AHTR7DRD3 | |
| SCHEMBL8918424 | 0.77 | HTR1A (0.51) | DRD4DRD2HTR1AHTR7DRD3 | |
| SCHEMBL9646262 | 0.76 | HTR1A (0.54) | HTR1AHTR7 | |
| SCHEMBL8920545 | 0.76 | SIGMAR1 (0.52) | DRD4DRD2HTR1AHTR7DRD3 | |
| SCHEMBL8921274 | 0.75 | ALDH1A1 (0.45) | DRD4HTR1AHTR7KMT2A | |
| SCHEMBL8918289 | 0.73 | MEN1 (0.45) | DRD4DRD2HTR1AHTR7DRD3 | |
| SCHEMBL8919147 | 0.72 | ALDH1A1 (0.37) | KMT2A | |
| SCHEMBL8919081 | 0.71 | PDE1B (0.41) | HTR1AHTR7 | |
| SCHEMBL9645860 | 0.71 | HTR1A (0.55) | HTR1AHTR7LMNA | |
| SCHEMBL8624408 | 0.70 | ALDH1A1 (0.36) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |