Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918622 | 0.91 | HRH3 (0.41) | TMEM97TP53MAPK1SIGMAR1HTR1A | |
| SCHEMBL8917996 | 0.89 | SIGMAR1 (0.44) | SIGMAR1HTR1A | |
| SCHEMBL8919139 | 0.84 | HRH3 (0.34) | TP53SIGMAR1HTR1AHRH3 | |
| SCHEMBL8920545 | 0.83 | SIGMAR1 (0.52) | SIGMAR1HTR1ADRD2 | |
| SCHEMBL8918611 | 0.81 | SIGMAR1 (0.41) | SIGMAR1HTR1ASLC6A4SLC6A3 | |
| SCHEMBL8630456 | 0.81 | PDE10A (0.36) | HTR1A | |
| SCHEMBL8628216 | 0.78 | PDE10A (0.35) | — | |
| SCHEMBL9464220 | 0.78 | HTR1A (0.60) | TMEM97TP53MAPK1SIGMAR1HTR1A | |
| SCHEMBL8919081 | 0.76 | PDE1B (0.41) | HTR1A | |
| SCHEMBL9464205 | 0.76 | HTR1A (0.61) | TMEM97TP53MAPK1SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |