Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918622 | 0.84 | HRH3 (0.41) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8918611 | 0.81 | SIGMAR1 (0.41) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8919139 | 0.81 | HRH3 (0.34) | HTR1AKDM1ASIGMAR1TP53PDE10A | |
| SCHEMBL8628216 | 0.78 | PDE10A (0.35) | L3MBTL1PDE10AALDH1A1PKMKMT2A | |
| SCHEMBL8918424 | 0.76 | HTR1A (0.51) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL8630456 | 0.76 | PDE10A (0.36) | HTR1AL3MBTL1PDE10AALDH1A1PKM | |
| SCHEMBL8917996 | 0.75 | SIGMAR1 (0.44) | HTR1ASIGMAR1ALDH1A1KMT2AHPGD | |
| SCHEMBL8624806 | 0.74 | HSD17B10 (0.35) | KDM1AL3MBTL1PDE10AALDH1A1PKM | |
| SCHEMBL8919081 | 0.73 | PDE1B (0.41) | HTR1AALDH1A1HPGDTSHRGAA | |
| SCHEMBL8917938 | 0.72 | PDE1B (0.43) | SIGMAR1ALDH1A1KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |