Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917938 | 0.88 | PDE1B (0.43) | PDE1BSMN1; SMN2KDM4EALDH1A1DCTPP1 | |
| SCHEMBL8918497 | 0.85 | DRD4 (0.53) | HTR1AHTR7ALDH1A1 | |
| SCHEMBL8918622 | 0.79 | HRH3 (0.41) | HTR1A | |
| SCHEMBL8624806 | 0.77 | HSD17B10 (0.35) | SMN1; SMN2KDM4ETSHRALDH1A1HPGD | |
| SCHEMBL8918611 | 0.77 | SIGMAR1 (0.41) | SMN1; SMN2TSHRHTR1AALDH1A1NOS3 | |
| SCHEMBL8628216 | 0.75 | PDE10A (0.35) | SMN1; SMN2KDM4ETSHRALDH1A1HPGD | |
| SCHEMBL8917996 | 0.75 | SIGMAR1 (0.44) | SMN1; SMN2HTR1AALDH1A1HPGDHSD17B10 | |
| SCHEMBL8919271 | 0.74 | ALDH1A1 (0.53) | KDM4ETSHRALDH1A1HPGD | |
| SCHEMBL8918424 | 0.74 | HTR1A (0.51) | HTR1AHTR7 | |
| SCHEMBL7326070 | 0.74 | ALDH1A1 (0.35) | SMN1; SMN2KDM4ETSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |