Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918611 | 0.89 | SIGMAR1 (0.41) | SIGMAR1SMN1; SMN2SYKALDH1A1LMNA | |
| SCHEMBL8919081 | 0.88 | PDE1B (0.41) | PDE1BSMN1; SMN2KDM4EHSD17B10DCTPP1 | |
| SCHEMBL8917996 | 0.86 | SIGMAR1 (0.44) | SIGMAR1SMN1; SMN2POLBHSD17B10KMT2A | |
| SCHEMBL8918497 | 0.83 | DRD4 (0.53) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8629045 | 0.78 | ALDH1A1 (0.41) | SIGMAR1POLBHSD17B10MEN1KMT2A | |
| SCHEMBL8918622 | 0.78 | HRH3 (0.41) | SIGMAR1SYKHRH3 | |
| SCHEMBL8918991 | 0.77 | PDE1B (0.46) | PDE1BSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL8624806 | 0.76 | HSD17B10 (0.35) | SMN1; SMN2KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL8628216 | 0.74 | PDE10A (0.35) | SMN1; SMN2KDM4EPOLBSYKHSD17B10 | |
| SCHEMBL8918424 | 0.73 | HTR1A (0.51) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618819-A | ANALGESICS | ADIR ET COMPAGNIE (FR) | 1997-04-08 | — | — | US | disclosed |
| EP-0691339-A1 | Amine derivatives of 1,3-dihydro-2H-pyrrolo(2,3-b)pyridin-2-ones and oxazolo(4,5-b)pyridin-2(3H)-ones, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-01-10 | — | — | EP | disclosed |