SCHEMBL8921486

SCHEMBL8921486

COc1cccc2c1C(=N)NC21OC(C)O1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.34
TXNRD1 Q16881 1/20 0.33
TXNRD3 Q86VQ6 1/20 0.33
TXNRD2 Q9NNW7 1/20 0.33
NR3C1 P04150 4/20 0.33
PGR P06401 1/20 0.33
NQO1 P15559 1/20 0.33
POR P16435 1/20 0.33
KMT2A Q03164 1/20 0.32
HTR1A P08908 2/20 0.32
HTR1D P28221 2/20 0.32
HTR2C P28335 2/20 0.32
HTR7 P34969 2/20 0.32
HTR5A P47898 2/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
POLL Q9UGP5 1/20 0.31
SIGMAR1 Q99720 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8919172 0.85 PDK2 (0.38) PDK2NR3C1KMT2AHTR1A
SCHEMBL8921225 0.83 PRKCA (0.34) HTR2C
SCHEMBL8921478 0.81 TXNRD1 (0.42) PDK2TXNRD1TXNRD3TXNRD2NR3C1
SCHEMBL8919135 0.80 PRKCA (0.43) KMT2A
SCHEMBL8919145 0.78
SCHEMBL7825538 0.75 PDK2 (0.39) PDK2TXNRD1TXNRD3TXNRD2KMT2A
SCHEMBL8919109 0.74 TDP1 (0.36) KMT2AHTR2CCA1CA2CA7
SCHEMBL7827148 0.70 PDK2 (0.35) PDK2TXNRD1TXNRD3TXNRD2KMT2A
SCHEMBL8920673 0.69 DHFR (0.35) HTR1A
SCHEMBL8920935 0.69 ALDH1A1 (0.35) PDK2PGRNQO1PORKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691272-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1997-11-25 US disclosed
US-5559247-A Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, INC. (JP) 1996-09-24 US disclosed
EP-0679640-A1 Carboxylate and heat-sensitive recording material using same MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-11-02 EP disclosed