Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921847 | 0.90 | LMNA (0.34) | L3MBTL1CYP19A1CYP17A1CCR1CCR2 | |
| SCHEMBL8920231 | 0.90 | CCKBR (0.31) | CCKBR | |
| SCHEMBL8924342 | 0.89 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL9362772 | 0.88 | HSD11B1 (0.36) | CCKBRHSD11B1L3MBTL1ALDH1A1P2RX7 | |
| SCHEMBL8923583 | 0.87 | L3MBTL1 (0.32) | HSD11B1L3MBTL1ALDH1A1CCR1CCR2 | |
| SCHEMBL9362140 | 0.83 | L3MBTL1 (0.33) | HSD11B1L3MBTL1ALDH1A1CCR1CCR2 | |
| SCHEMBL8922628 | 0.83 | PLA2G10 (0.35) | CCKBRL3MBTL1ALDH1A1CCR1CCR2 | |
| SCHEMBL8926039 | 0.81 | DRD2 (0.32) | CCKBRL3MBTL1ALDH1A1 | |
| SCHEMBL8922132 | 0.81 | CCKBR (0.34) | CCKBRHSD11B1L3MBTL1ALDH1A1CYP19A1 | |
| SCHEMBL9541317 | 0.78 | LMNA (0.38) | CCKBRHSD11B1L3MBTL1ALDH1A1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |