Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGLRA1GLRBKCNK10KCNK18KCNK2KCNK3KCNK9
The experimentally established mechanism targets of Enflurane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enflurane SCHEMBL61712 | 0.87 | MEN1 (0.39) | MEN1KMT2A | |
| Enflurane SCHEMBL4056349 | 0.87 | MEN1 (0.39) | MEN1KMT2A | |
| SCHEMBL11617262 | 0.78 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MEN1KMT2A | |
| Enflurane SCHEMBL13723343 | 0.73 | TSHR (0.35) | MEN1KMT2A | |
| Halothane SCHEMBL337605 | 0.72 | — | — | |
| Halothane SCHEMBL25588 | 0.72 | — | — | |
| Halothane SCHEMBL443681 | 0.72 | — | — | |
| Halothane SCHEMBL1612295 | 0.72 | HSD17B10 (1.00) | ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL11617110 | 0.72 | MEN1 (0.36) | ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL11419898 | 0.71 | MEN1 (0.39) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0704054-A1 | DETERMINING GAS CONCENTRATION | ISIS INNOVATION (GB) | 1996-04-03 | — | — | EP | disclosed |
| WO-1995000838-A1 | DETERMINING GAS CONCENTRATION | ISIS INNOVATION LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |