Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | PDE6A | P16499 | 1/20 | 0.33 |
| ▸ | PDE6G | P18545 | 1/20 | 0.33 |
| ▸ | PDE6B | P35913 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8941625 | 0.80 | ELANE (0.37) | ELANEGRM2TACR3PDE2APDE10A | |
| SCHEMBL8941655 | 0.73 | KMT2A (0.37) | GRM2PDE2APDE10AGAAALDH1A1 | |
| SCHEMBL8941652 | 0.64 | KMT2A (0.37) | GRM2PDE2APDE10AMAPTGAA | |
| SCHEMBL8941633 | 0.61 | PLA2G7 (0.39) | GRM2PDE2APDE10AMAPTLMNA | |
| SCHEMBL9358713 | 0.58 | GAA (0.50) | MAPTLMNAGAATSHRHTT | |
| SCHEMBL18520686 | 0.58 | BRAF (0.36) | ELANEGRM2PDE2APDE10AHSD17B10 | |
| SCHEMBL6139499 | 0.58 | EPHX2 (0.39) | MAPTLMNAGAATSHRHTT | |
| SCHEMBL9890698 | 0.57 | CASP1 (0.44) | TACR3MAPTAKR1C3AKR1C2LMNA | |
| SCHEMBL31449953 | 0.56 | TSHR (0.41) | MAPTAKR1C3AKR1C2LMNATSHR | |
| SCHEMBL13403891 | 0.56 | CXCL8 (0.46) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996019444-A1 | SULFONATE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |
| US-5510379-A | USEFUL FOR TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-04-23 | — | — | US | disclosed |