SCHEMBL8943946

SCHEMBL8943946

COc1ccc(N(c2ccc(C)cc2)c2cccc(OCCOc3cccc(N(c4ccc(C)cc4)c4ccc(OC)cc4)c3)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.48
ALDH1A1 P00352 2/20 0.46
POLB P06746 1/20 0.46
MAPK1 P28482 1/20 0.44
ACHE P22303 1/20 0.44
DRD2 P14416 1/20 0.43
DRD4 P21917 1/20 0.43
DRD3 P35462 1/20 0.43
GAA P10253 1/20 0.43
SLC2A1 P11166 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
ALOX15 P16050 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ADRA2A P08913 2/20 0.41
ADRA1A P35348 2/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41
ADRA1D P25100 1/20 0.41
ADRA1B P35368 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8944183 0.89 DRD2 (0.44) MAOBPOLBMAPK1DRD2DRD4
SCHEMBL11887991 0.88 DRD2 (0.48) MAOBDRD2DRD4DRD3MAPT
SCHEMBL8943634 0.87 DRD2 (0.49) MAOBMAPK1DRD2DRD4DRD3
SCHEMBL8943706 0.86 ACHE (0.56) ALDH1A1ACHEDRD2DRD4DRD3
SCHEMBL10445865 0.84 MTNR1A (0.47) DRD2DRD4DRD3MTNR1AMTNR1B
SCHEMBL8943776 0.83 HSD17B1 (0.50) MAOBACHEL3MBTL1ALOX15TDP1
SCHEMBL14340638 0.83 ACHE (0.50) MAOBACHEALOX15ADRA2AADRA1A
SCHEMBL11887992 0.83 MAOB (0.42) MAOBALDH1A1POLBDRD2DRD4
SCHEMBL8944101 0.82 HSD17B2 (0.50) ALDH1A1ACHEALOX15MTNR1AMTNR1B
SCHEMBL13929902 0.81 ACHE (0.48) MAOBACHEALOX15ADRA2AADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5480765-A PRESSURE AND HEAT SENSITIVE PAPER, IMPROVED PHOTOSTABILITY BY ADDITION OF TRIARYLAMINE COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1996-01-02 US disclosed