Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19257958 | 0.80 | PTPRB (0.47) | SLC6A2SLC6A4PTPRBADRB3CCR3 | |
| SCHEMBL19257745 | 0.77 | CCR3 (0.39) | SLC6A2SLC6A4NPC1ALDH1A1RAB9A | |
| SCHEMBL22267911 | 0.77 | CCR3 (0.39) | SLC6A2SLC6A4NPC1ALDH1A1RAB9A | |
| SCHEMBL8945917 | 0.77 | NOS1 (0.34) | — | |
| SCHEMBL8945781 | 0.76 | — | — | |
| SCHEMBL8946017 | 0.76 | ALOX5 (0.33) | ALDH1A1 | |
| SCHEMBL8945905 | 0.76 | YTHDC1 (0.33) | — | |
| SCHEMBL8945988 | 0.76 | YTHDC1 (0.33) | SLC6A2SLC6A4NPC1ALDH1A1RAB9A | |
| SCHEMBL8945903 | 0.75 | LTA4H (0.36) | SLC6A2SLC6A4GAA | |
| SCHEMBL8945955 | 0.75 | TSHR (0.38) | SLC6A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0322582-A2 | 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-07-05 | — | — | EP | disclosed |