Sugi Predict

Sugi Predict / Compounds / SCHEMBL8948701

SCHEMBL8948701

SCHEMBL8948701

O=C(CCc1ccc(I)cc1)ON1C(=O)CCC1=O

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ PSMB8 P28062 2/20 0.37
▸ PSMB5 P28074 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ CYP4F2 P78329 1/20 0.36
▸ CYP4A11 Q02928 1/20 0.36
▸ HRH3 Q9Y5N1 2/20 0.34
▸ HRH4 Q9H3N8 1/20 0.34
▸ HTR2A P28223 1/20 0.33
▸ HTR2C P28335 1/20 0.33
▸ HTR7 P34969 1/20 0.33
▸ HTR6 P50406 1/20 0.33
▸ MGLL Q99685 1/20 0.32
▸ FAAH O00519 1/20 0.32
▸ APP P05067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19658184 0.92 TDP1 (0.42) PSMB8PSMB5TDP1CYP4F2CYP4A11
SCHEMBL19743116 0.91 HRH4 (0.43) HRH3HRH4MGLLFAAH
SCHEMBL22488336 0.90 HRH4 (0.39) HRH3HRH4MGLLFAAH
SCHEMBL112099 0.86 FAAH (0.41) PSMB8PSMB5TDP1CYP4F2CYP4A11
SCHEMBL20530034 0.86 KMT2A (0.41) CYP4F2CYP4A11HRH3MGLL
SCHEMBL6193414 0.85 MGLL (0.44) MGLLFAAH
SCHEMBL13920679 0.85 FFAR1 (0.42) PSMB8PSMB5TDP1CYP4F2CYP4A11
SCHEMBL18353920 0.85 PSMB8 (0.37) PSMB8PSMB5TDP1CYP4F2CYP4A11
SCHEMBL9752036 0.85 L3MBTL1 (0.43) PSMB8PSMB5TDP1CYP4F2CYP4A11
SCHEMBL436079 0.84 TDP1 (0.54) PSMB8PSMB5TDP1MGLLFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240294964-A1 FUNTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS RATIO THERAPEUTICS, INC. 2024-09-05 — — US disclosed
US-11939617-B2 Functionally modified polypeptides and radiobiosynthesis IKARIA INC. (US) 2024-03-26 — — US disclosed
US-20230332199-A1 FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS RATIO THERAPEUTICS, INC. 2023-10-19 — — US disclosed
US-20230332199-A1 FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS RATIO THERAPEUTICS, INC. 2023-10-19 — — US disclosed
US-20230332199-A1 FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS RATIO THERAPEUTICS, INC. 2023-10-19 — — US disclosed
US-20220009883-A1 THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF RATIO THERAPEUTICS, INC. 2022-01-13 — — US disclosed
US-11214820-B2 Functionally modified polypeptides and radiobiosynthesis IKARIA INC. (US) 2022-01-04 — — US disclosed
US-11214820-B2 Functionally modified polypeptides and radiobiosynthesis IKARIA INC. (US) 2022-01-04 — — US disclosed
EP-3880253-A1 THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF Noria Therapeutics, Inc. (US) 2021-09-22 — — EP disclosed
WO-2020102348-A1 THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF DIMAGNO STEPHEN (US) 2020-05-22 — — WO disclosed
WO-2018045376-A2 FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS IKARIA INC. (US) 2018-03-08 — — WO disclosed
US-20180066298-A1 FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS RATIO THERAPEUTICS, INC. 2018-03-08 — — US disclosed
US-20170001957-A1 RADIOIODINATED BIOCONJUGATION REAGENTS NUTECH VENTURES (US) 2017-01-05 — — US disclosed
US-20170001957-A1 RADIOIODINATED BIOCONJUGATION REAGENTS NUTECH VENTURES (US) 2017-01-05 — — US disclosed
US-20170001957-A1 RADIOIODINATED BIOCONJUGATION REAGENTS NUTECH VENTURES (US) 2017-01-05 — — US disclosed
WO-2016201125-A1 RADIOIODINATED BIOCONJUGATION REAGENTS NUTECH VENTURES (US) 2016-12-15 — — WO disclosed
US-5569446-A Radiohalogenation of proteins using trihalophenyl derivatives BRACCO INTERNATIONAL B.V. 1996-10-29 — — US disclosed
US-5463080-A 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents BRACCO INTERNATIONAL B.V. (NL) 1995-10-31 — — US disclosed
US-5290937-A Radiolabeling of proteins using alkoxyphenol derivatives E. R. SQUIBB & SONS, INC. (US) 1994-03-01 — — US disclosed
EP-0203764-B1 RADIOHALOGENATED SMALL MOLECULES FOR PROTEIN LABELING NEORX CORPORATION (US) 1993-03-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240294964-A1 FUNTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS IL1RN, IL2RA, IL1A PSMB8 1608/4885PSMB5 2643/4885TDP1 3608/4885
US-11939617-B2 Functionally modified polypeptides and radiobiosynthesis IL1RN, IL2RA, IL1A PSMB8 1000/4885PSMB5 2617/4885TDP1 3019/4885
US-20230332199-A1 FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS IL1RN, IL2RA, IL1A PSMB8 1000/4885PSMB5 2617/4885TDP1 3019/4885
US-20220009883-A1 THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF ALB, TTR, ABCG2 PSMB8 1456/4885PSMB5 1694/4885TDP1 2183/4885
US-20170001957-A1 RADIOIODINATED BIOCONJUGATION REAGENTS TPO, TSHR, HLCS PSMB8 3264/4885PSMB5 3656/4885TDP1 1810/4885
US-11214820-B2 Functionally modified polypeptides and radiobiosynthesis IL1RN, IL2RA, IL1A PSMB8 1000/4885PSMB5 2617/4885TDP1 3019/4885
US-20180066298-A1 FUNCTIONALLY MODIFIED POLYPEPTIDES AND RADIOBIOSYNTHESIS IL1RN, IL2RA, IL1A PSMB8 1000/4885PSMB5 2617/4885TDP1 3019/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.