SCHEMBL8948735

SCHEMBL8948735

O=c1cc(C(F)(F)F)n(-c2cccc3ccoc23)c(=O)[nH]1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.35
DRD2 P14416 2/20 0.35
TSHR P16473 1/20 0.32
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9275529 0.80 BCAT1 (0.48)
SCHEMBL8175657 0.72 CRBN (0.44)
SCHEMBL7833292 0.69 NOTUM (0.48) TSHRHPGD
SCHEMBL8175658 0.68 HTR1A (0.36) HTR1ADRD2
SCHEMBL29575271 0.66 BCAT1 (0.36) TSHR
SCHEMBL31442417 0.66 HCAR1 (0.40)
SCHEMBL8086309 0.66 ESR1 (0.41) TSHRHPGD
SCHEMBL8129531 0.65 HCAR1 (0.38) TSHRHPGD
SCHEMBL8087404 0.65 KDM4E (0.36) TSHR
SCHEMBL1527275 0.65 LMNA (0.40) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521147-A HERBICIDES FMC CORPORATION (US) 1996-05-28 US disclosed
WO-1995005079-A1 3-(BENZOFURAN-7-YL)-6-HALOALKYLURACILS FMC CORPORATION (US) 1995-02-23 WO disclosed