Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.50 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20522128 | 0.84 | HCAR1 (0.44) | MGLLHCAR1HSD11B1HTR1FPIK3CA | |
| SCHEMBL8953658 | 0.80 | HSD11B1 (0.37) | MGLLHSD11B1HTR1FPIK3CAAKT1 | |
| SCHEMBL31155300 | 0.77 | CES2 (0.52) | MGLLHSD11B1HTR1FSMN1; SMN2 | |
| SCHEMBL22519116 | 0.76 | HSD11B1 (0.59) | MGLLHSD11B1ALDH1A1GAA | |
| SCHEMBL20521903 | 0.76 | ALDH1A1 (0.42) | PIK3CACA12CA1CA9ALDH1A1 | |
| SCHEMBL8953639 | 0.75 | MGLL (0.57) | MGLLCA12CA1CA9ALDH1A1 | |
| SCHEMBL8953741 | 0.75 | KMT2A (0.50) | ALDH1A1 | |
| SCHEMBL8410878 | 0.74 | MAP4K4 (0.52) | MGLLHDAC3HDAC1HDAC2SLC6A9 | |
| SCHEMBL8953638 | 0.73 | HRH3 (0.40) | ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9308150 | 0.72 | MGLL (0.34) | MGLLHSD11B1CHEK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484786-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-01-16 | — | — | US | disclosed |
| US-5354865-A | Enzyme inhibitor and inhibiting the leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1994005281-A1 | PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1994-03-17 | — | — | WO | disclosed |