Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28057544 | 0.82 | SRD5A2 (0.42) | — | |
| SCHEMBL19207667 | 0.72 | MMP2 (0.59) | MMP2HPGDSALDH1A1LMNAKDM4E | |
| SCHEMBL9367898 | 0.72 | HRH1 (0.42) | ALDH1A1LMNAKDM4E | |
| SCHEMBL4494347 | 0.72 | HPGDS (0.54) | HPGDSCAPN1DAOTAAR1 | |
| SCHEMBL7846648 | 0.71 | MMP2 (0.51) | MMP2HPGDSRNASEH1ALDH1A1CAPN1 | |
| SCHEMBL23337994 | 0.71 | MMP2 (0.50) | MMP2HPGDSRNASEH1ALDH1A1DAO | |
| SCHEMBL7345076 | 0.71 | BRS3 (0.49) | MMP2HPGDSRNASEH1CAPN1DAO | |
| SCHEMBL9314265 | 0.70 | KEAP1 (0.50) | MMP2HPGDSCAPN1DAOKDM4E | |
| SCHEMBL7688678 | 0.68 | HPGDS (0.50) | HPGDSCAPN1DAOBRS3TAAR1 | |
| SCHEMBL4439049 | 0.68 | HPGDS (0.50) | HPGDSRNASEH1CAPN1DAOBRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536262-A4 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORP (US) | 1996-08-14 | — | — | EP | disclosed |
| EP-0541705-A4 | SUBSTITUTED 1H-IMIDAZOL-5-YL)ALKANOIC ACIDS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0541705-A1 | SUBSTITUTED 1H-IMIDAZOL-5-YL]ALKANOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0536262-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | disclosed |