Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080904 | 0.86 | LMNA (0.43) | LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7080985 | 0.76 | — | — | |
| SCHEMBL8618922 | 0.76 | SOAT2 (0.58) | — | |
| SCHEMBL9386678 | 0.75 | NLRP3 (0.47) | — | |
| SCHEMBL9059769 | 0.75 | FAAH (0.41) | LMNA | |
| SCHEMBL11234113 | 0.73 | L3MBTL1 (0.63) | LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7104643 | 0.73 | — | — | |
| SCHEMBL27582526 | 0.72 | NOTUM (0.45) | LMNASMN1; SMN2 | |
| SCHEMBL8941158 | 0.72 | — | — | |
| SCHEMBL7082105 | 0.72 | NLRP3 (0.50) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491170-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1996-02-13 | — | — | US | disclosed |
| WO-1994003438-A1 | SULFONAMIDE TETRAZOLE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |