SCHEMBL8966971

SCHEMBL8966971

Bc1cccc(Cl)c1N(CC)CC

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.37
S1PR1 P21453 5/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
ALDH1A1 P00352 2/20 0.33
LMNA P02545 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP1A2 P05177 1/20 0.31
CYP2A6 P11509 1/20 0.31
TP53 P04637 1/20 0.31
ESR1 P03372 2/20 0.31
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
TSHR P16473 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30
DRD2 P14416 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8966248 0.85 CRHR1 (0.42) KDM4ES1PR1ESR1DRD2DRD3
SCHEMBL8966927 0.82 LMNA (0.35) KDM4ESMN1; SMN2ALDH1A1LMNAESR1
SCHEMBL8967009 0.77 CYP1A2 (0.35) SMN1; SMN2ALDH1A1LMNACYP1A2CYP2A6
SCHEMBL14860191 0.76 S1PR1 (0.34) KDM4ES1PR1SMN1; SMN2ALDH1A1LMNA
SCHEMBL2102108 0.76 KDM4E (0.37) KDM4ES1PR1SMN1; SMN2ALDH1A1LMNA
SCHEMBL8967322 0.72 CYP1A2 (0.34) ALDH1A1LMNACYP3A4CYP1A2CYP2A6
SCHEMBL19111974 0.70 TAAR1 (0.38) KDM4ESMN1; SMN2LMNACYP1A2CYP2A6
SCHEMBL2102543 0.69 TP53 (0.36) S1PR1SMN1; SMN2ALDH1A1LMNACYP3A4
SCHEMBL2102669 0.69 CYP1A2 (0.33) S1PR1SMN1; SMN2ALDH1A1LMNACYP3A4
SCHEMBL29212162 0.68 ALDH1A1 (0.40) KDM4ESMN1; SMN2ALDH1A1CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0519496-B1 Thermosetting copolymers, silicon carbide-based fiber and processes for producing same TONEN CORP (JP) 1996-05-22 EP disclosed
EP-0404503-B1 Boron-containing, silicon nitride-based ceramic shaped body production process TONEN CORP (JP) 1996-03-06 EP disclosed
EP-0389084-B1 Process for producing a polyborosilazane TONEN CORP (JP) 1995-09-20 EP disclosed
US-5292830-A Silane, silazane, boron block crosslinked copolymers TONEN CORPORATION (JP) 1994-03-08 US disclosed
EP-0519496-A1 Thermosetting copolymers, silicon carbide-based fiber and processes for producing same Tonen Corporation (JP) 1992-12-23 EP disclosed
US-5128286-A BORON-CONTAINING, SILICON NITRIDE-BASED CERAMIC SHAPED BODY TONEN CORPORATION (JP) 1992-07-07 US disclosed
US-5030744-A Polyborosilazane and process for producing same TONEN CORPORATION (JP) 1991-07-09 US disclosed