Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Furfural. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 7/20 | 0.44 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.95 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | POLB | P06746 | 7/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MASP2 | O00187 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furfural SCHEMBL28976274 | 1.00 | — | — | |
| Furfural SCHEMBL20439 | 0.97 | — | — | |
| Furfural SCHEMBL626705 | 0.97 | ALDH1A1 (1.00) | ALDH1A1HCAR2MAPTPOLBL3MBTL1 | |
| Furfural SCHEMBL10811266 | 0.97 | ALDH1A1 (1.00) | ALDH1A1HCAR2MAPTPOLBL3MBTL1 | |
| Furfural SCHEMBL11720194 | 0.95 | — | — | |
| Furfural SCHEMBL11763411 | 0.95 | — | — | |
| Furfural SCHEMBL2978794 | 0.95 | — | — | |
| Furfural SCHEMBL29854165 | 0.95 | — | — | |
| Furfural SCHEMBL2197116 | 0.95 | — | — | |
| Furfural SCHEMBL29491010 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240367156-A1 | IRON-COBALT-BASED MAGNETICALLY RECOVERABLE CATALYSTS AND METHOD OF PREPARATION THEREOF | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2024-11-07 | — | — | US | disclosed |
| CN-110330470-B | Method for purifying biomass-based furan compounds by Schiff base reaction | 广西科学院 | 2022-02-01 | — | — | CN | disclosed |
| CN-111057594-B | Preparation method of alcohol-based fuel additive | 李旭 | 2021-10-29 | — | — | CN | disclosed |
| CN-111057594-A | Preparation method of alcohol-based fuel additive | 李旭 | 2020-04-24 | — | — | CN | disclosed |
| CN-110330470-A | A method of realizing that biomass-based furfuran compound purifies using Schiff reaction | 广西科学院 | 2019-10-15 | — | — | CN | disclosed |
| CN-105801528-B | With metal catalyst reduction HMF ether | 阿彻丹尼尔斯米德兰德公司 | 2019-06-21 | — | — | CN | disclosed |
| US-9783516-B2 | Reduction of HMF ethers with metal catalyst | ARCHER DANIELS MIDLAND CO. (US) | 2017-10-10 | — | — | US | disclosed |
| CN-104744414-B | Oxidation Of Furfural Compounds | 阿彻丹尼尔斯米德兰德公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-103626639-B | With metal catalyst reduction HMF ether | 阿彻丹尼尔斯米德兰德公司 | 2016-12-07 | — | — | CN | disclosed |
| US-20160297788-A1 | REDUCTION OF HMF ETHERS WITH METAL CATALYST | ARCHER DANIELS MIDLAND CO (US) | 2016-10-13 | — | — | US | disclosed |
| US-20090131690-A1 | METHOD FOR THE SYNTHESIS OF 5-ALKOXYMETHYL FURFURAL ETHERS AND THEIR USE | FURANIX TECHNOLOGIES B.V. (NL) | 2009-05-21 | — | — | US | disclosed |
| EP-2004620-A2 | METHOD FOR THE SYNTHESIS OF 5-ALKOXYMETHYL FURFURAL ETHERS AND THEIR USE | Furanix Technologies B.V (NL) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007104514-A3 | METHOD FOR THE SYNTHESIS OF 5-ALKOXYMETHYL FURFURAL ETHERS AND THEIR USE | AVANTIUM INT BV (NL) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007104514-A2 | METHOD FOR THE SYNTHESIS OF 5-ALKOXYMETHYL FURFURAL ETHERS AND THEIR USE | FURANIX TECHNOLOGIES B.V. (NL) | 2007-09-20 | — | — | WO | disclosed |
| EP-1027288-B1 | STABILIZED CONCENTRATES OF WATER UNSTABLE AZA COMPOUNDS AND O/W MINIEMULSIONS THEREOF | ISP INVESTMENTS INC (US) | 2003-09-03 | — | — | EP | disclosed |
| EP-1027288-A4 | STABILIZED CONCENTRATES OF WATER UNSTABLE AZA COMPOUNDS AND O/W MINIEMULSIONS THEREOF | ISP INVESTMENTS INC (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6255350-B1 | OIL IN WATER MICROEMULSION | ISP INVESTMENTS INC. | 2001-07-03 | — | — | US | disclosed |
| EP-1027288-A2 | STABILIZED CONCENTRATES OF WATER UNSTABLE AZA COMPOUNDS AND O/W MINIEMULSIONS THEREOF | ISP INVESTMENTS INC. (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999019256-A2 | STABILIZED CONCENTRATES OF WATER UNSTABLE AZA COMPOUNDS AND O/W MINIEMULSIONS THEREOF | ISP INVESTMENTS INC. (US) | 1999-04-22 | — | — | WO | disclosed |
| CN-1034159-A | No Rubber compacting corn stalk Wood-based Panel Production technology | SIPING CITY CEMENT PLANT JILIN (CN) | 1989-07-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297788-A1 | REDUCTION OF HMF ETHERS WITH METAL CATALYST | PHF2, ZRANB2, TERF2 | MEN1 129/4885THRB 4051/4885ALDH1A1 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.