Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968118 | 1.00 | RAB9A (0.35) | RAB9ASIGMAR1OPRK1ARKDM4E | |
| SCHEMBL8967753 | 0.77 | SIGMAR1 (0.41) | RAB9ASIGMAR1ARKDM4EALDH1A1 | |
| SCHEMBL8967681 | 0.69 | SIGMAR1 (0.40) | RAB9ASIGMAR1OPRK1ARALDH1A1 | |
| Maleic Acid SCHEMBL8967637 | 0.69 | NPC1 (0.43) | RAB9AALDH1A1LMNATDP1HTT | |
| Fumaric Acid SCHEMBL8968115 | 0.69 | NPC1 (0.43) | RAB9AALDH1A1LMNATDP1HTT | |
| SCHEMBL8967939 | 0.65 | KAT2B (0.50) | RAB9AALDH1A1LMNAHTTMAPT | |
| Hydrochloric Acid SCHEMBL8968053 | 0.64 | KAT2B (0.51) | RAB9AALDH1A1LMNAHTTMAPT | |
| SCHEMBL8618010 | 0.63 | ALDH1A1 (0.44) | RAB9ASIGMAR1OPRK1ARKDM4E | |
| SCHEMBL9543595 | 0.62 | KDM4E (0.50) | KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8555791 | 0.62 | MAPT (0.47) | RAB9AALDH1A1LMNATDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530138-A | A PYRROLIZINE DERIVATIVE; EFFECTIVE IN THE TREATMENT OF SENILE DEMENTIA | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |