Sugi Predict

Sugi Predict / Compounds / SCHEMBL896879

SCHEMBL896879

SCHEMBL896879

CC(C)(C)[Si](C)(C)Oc1ccc(C=O)cc1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.50
▸ CYP2A6 P11509 2/20 0.50
▸ PREP P48147 4/20 0.46
▸ ALDH1A3 P47895 1/20 0.46
▸ CA12 O43570 4/20 0.45
▸ CA1 P00915 4/20 0.45
▸ CA9 Q16790 4/20 0.45
▸ KDM4E B2RXH2 3/20 0.42
▸ LMNA P02545 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ STS P08842 1/20 0.40
▸ MAPT P10636 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ DRD1 P21728 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ PARP10 Q53GL7 1/20 0.37
▸ PARP3 Q9Y6F1 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4890854 0.95 PREP (0.50) ALDH1A1CYP2A6PREPALDH1A3CA12
SCHEMBL6027756 0.95 ALDH1A1 (0.46) ALDH1A1CYP2A6PREPALDH1A3CA12
SCHEMBL17494817 0.93 ALDH1A1 (0.44) ALDH1A1CYP2A6PREPALDH1A3CA12
4-Hydroxybenzaldehyde SCHEMBL17494799 0.92 ALDH5A1 (0.52) ALDH1A1CYP2A6PREPALDH1A3CA12
Piperidine SCHEMBL1082681 0.86 PREP (0.41) ALDH1A1CYP2A6PREPALDH1A3CA12
SCHEMBL1161803 0.84 CA12 (0.56) ALDH1A1CYP2A6PREPALDH1A3CA12
SCHEMBL7189378 0.84 CA12 (0.46) ALDH1A1PREPCA12CA1CA9
SCHEMBL6763899 0.83 PREP (0.53) ALDH1A1PREPCA12CA1CA9
SCHEMBL3139506 0.82 CA12 (0.54) ALDH1A1CYP2A6PREPALDH1A3CA12
SCHEMBL10408600 0.81 ALDH1A1 (0.43) ALDH1A1CYP2A6PREPALDH1A3KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 — — US claimed
US-11939332-B2 Synthesis of coelenterazine INTERNATIONAL PAPER COMPANY (US) 2024-03-26 — — US claimed
EP-3830088-A1 SYNTHESIS OF COELENTERAZINE International Paper Company (US) 2021-06-09 — — EP claimed
CN-112920039-A Diarylacetylene compound containing methylene quinone, preparation method and application thereof 大连理工大学 2021-06-08 — — CN claimed
US-20210070762-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY (US) 2021-03-11 — — US claimed
CN-112368286-A Synthesis of coelenterazine 国际纸业公司 2021-02-12 — — CN claimed
CN-105294725-A Asymmetric synthesis method for natural products Aculeatins A, B, D and 6-epi-Aculeatin D UNIV JIANGXI NORMAL SCI & TECH 2016-02-03 — — CN claimed
CN-103562296-B The manufacture method of rubber combination BRIDGESTONE CO.,LTD. (JP) 2015-11-25 — — CN claimed
US-12251370-B2 Small molecule inhibitors of the BfrB:Bfd interaction BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2025-03-18 — — US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 — — US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 — — US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 — — US disclosed
WO-2024105686-A1 A PROCESS FOR THE SYNTHESIS OF STILBENE AND INTERMEDIATES THEREOF FERTIS INDIA PVT LTD (IN) 2024-05-23 — — WO disclosed
US-11964953-B2 Substituted aminothiazoles as DGKzeta inhibitors for immune activation BAYER AKTIENGESELLSCHAFT (DE) 2024-04-23 — — US disclosed
US-5686478-A Endothelin antagonists MERCK & CO. INC. (US) 1997-11-11 — — US disclosed
EP-0805132-A1 Method of producing styrene derivatives HONSHU CHEMICAL INDUSTRY CO. LTD. (JP) 1997-11-05 — — EP disclosed
US-5633246-A Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents SCHERING CORPORATION (US) 1997-05-27 — — US disclosed
US-5624920-A Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents SCHERING CORPORATION (US) 1997-04-29 — — US disclosed
WO-1995003295-A1 ENDOTHELIN ANTAGONISTS MERCK & CO., INC. (US) 1995-02-02 — — WO disclosed
US-4895871-A Benzoheterocyclyl ketone hydrazone insecticides FMC CORPORATION (US) 1990-01-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11939332-B2 Synthesis of coelenterazine ACHE, UROD, DDT ALDH1A1 313/4885CYP2A6 402/4885PREP 133/4885
US-12251370-B2 Small molecule inhibitors of the BfrB:Bfd interaction BLVRB, TFPI, ETFB ALDH1A1 2584/4885CYP2A6 2851/4885PREP 932/4885
US-11964953-B2 Substituted aminothiazoles as DGKzeta inhibitors for immune activation DGKZ, DGKA, DGKG ALDH1A1 3985/4885CYP2A6 3487/4885PREP 3444/4885
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE ACHE, UROD, DDT ALDH1A1 313/4885CYP2A6 402/4885PREP 133/4885
US-20210070762-A1 SYNTHESIS OF COELENTERAZINE ACHE, UROD, DDT ALDH1A1 313/4885CYP2A6 402/4885PREP 133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.