Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.32 |
| ▸ | TACR2 | P21452 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SHBG | P04278 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14838178 | 0.77 | CHRM2 (0.47) | ADRA2ASLC6A2SLC6A4SLC6A3CHRM2 | |
| SCHEMBL7528457 | 0.74 | CA2 (0.52) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL9157653 | 0.73 | NPC1 (0.41) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL3188727 | 0.71 | ESR1 (0.61) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL3663793 | 0.71 | ESR1 (0.61) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL30658145 | 0.69 | LPL (0.48) | ALDH1A1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL9155362 | 0.69 | TSHR (0.57) | HSD17B10 | |
| SCHEMBL111932 | 0.68 | HSD11B1 (0.49) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL35210080 | 0.68 | HSD11B1 (0.49) | ALDH1A1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL9153598 | 0.68 | RARB (0.59) | ALDH1A1TBXAS1NPC1MAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644888-B1 | SULPHONIUM SALTS AND PROCESS FOR PRODUCING THEM | WACKER CHEMIE GMBH (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5466845-A | Contain silane groups, photoinitiators | WACKER-CHEMIE GMBH (DE) | 1995-11-14 | — | — | US | disclosed |
| EP-0644888-A1 | SULPHONIUM SALTS AND PROCESS FOR PRODUCING THEM. | WACKER CHEMIE GMBH (DE) | 1995-03-29 | — | — | EP | disclosed |
| WO-1993025559-A1 | SULPHONIUM SALTS AND PROCESS FOR PRODUCING THEM | WACKER-CHEMIE GMBH (DE) | 1993-12-23 | — | — | WO | disclosed |