Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970281 | 1.00 | CHRM2 (0.43) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL9382674 | 0.76 | CHRM2 (0.45) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL9382677 | 0.74 | ADRA1D (0.42) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL8969041 | 0.73 | CHRM2 (0.51) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL8970407 | 0.73 | SIGMAR1 (0.53) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL8971218 | 0.73 | HTR1A (0.59) | HTR1ADRD2HTR2A | |
| SCHEMBL8996726 | 0.73 | HTR1A (0.49) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL8970496 | 0.73 | CHRM2 (0.48) | CHRM2CHRM1CHRM3MTNR1AMTNR1B | |
| SCHEMBL8969531 | 0.72 | HTR7 (0.55) | CHRM2CHRM1CHRM3HTR1ADRD2 | |
| SCHEMBL8970307 | 0.72 | MTNR1A (0.62) | CHRM2CHRM1CHRM3MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |