Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4270841 | 0.78 | ALDH1A1 (0.40) | SIGMAR1 | |
| SCHEMBL8971103 | 0.77 | MAOA (0.51) | MAOAMEN1KMT2AKCNH2SLC6A3 | |
| SCHEMBL30484775 | 0.76 | SIGMAR1 (0.66) | MAOASLC6A3SIGMAR1S1PR1S1PR3 | |
| SCHEMBL26027613 | 0.73 | MAOA (0.50) | MAOASLC6A3SIGMAR1DRD2DRD4 | |
| SCHEMBL9387391 | 0.73 | CYP2D6 (0.47) | MEN1KMT2ASIGMAR1HTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL1399926 | 0.72 | LMNA (0.38) | DRD2DRD4 | |
| SCHEMBL8108965 | 0.72 | SLC6A3 (0.66) | MEN1KMT2AKCNH2SLC6A3SIGMAR1 | |
| SCHEMBL486687 | 0.72 | SLC6A3 (0.66) | MEN1KMT2AKCNH2SLC6A3SIGMAR1 | |
| SCHEMBL10902405 | 0.71 | MEN1 (0.67) | MEN1KMT2AKCNH2SLC6A3SIGMAR1 | |
| SCHEMBL28039452 | 0.71 | SIGMAR1 (0.47) | MEN1KMT2AKCNH2SIGMAR1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480892-A | SIGMA RECEPTOR ANTAGONISTS; TREATMENT OF PHYSIOLOGICAL OR DRUG INDUCED PSYCHOSIS AND DYSKINESIA | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-01-02 | — | — | US | disclosed |
| US-5356906-A | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1993022310-A1 | (N-PHTHALIMIDOALKYL)PIPERIDINES FOR THE TREATMENT OF PSYCHOSES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-11 | — | — | WO | disclosed |