Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.96 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.64 |
| ▸ | FDPS known ✓ | P14324 | 3/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.45 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586952 | 1.00 | CA1 (0.96) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL28024784 | 1.00 | CA1 (0.96) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL1998732 | 1.00 | CA1 (0.96) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL17581512 | 1.00 | CA1 (0.96) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL28727420 | 1.00 | CA1 (0.96) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL28727500 | 1.00 | CA1 (0.96) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL15022175 | 0.98 | CA1 (0.95) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL8678860 | 0.98 | CA1 (1.00) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL15022016 | 0.98 | CA1 (0.95) | CA1CA2GPR84NFKB1ACE2 | |
| SCHEMBL15022951 | 0.98 | CA1 (0.95) | CA1CA2GPR84NFKB1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0323723-B1 | Process for producing poly (para-phenylene-sulfide) | TOSOH CORP (JP) | 1996-09-25 | — | — | EP | disclosed |
| EP-0411625-B1 | Method to produce poly(arylene sulfide/sulfone) polymer | PHILLIPS PETROLEUM CO (US) | 1996-05-08 | — | — | EP | disclosed |
| US-5151495-A | Dehydration of a sulfide component, mixing with dihalobenzenes | TOSOH CORPORATION (JP) | 1992-09-29 | — | — | US | disclosed |
| US-5008368-A | Preparation of poly(arylene sulfide/sulfone) polymer with addition of water after polymerization is initiated | PHILLIPS PETROLEUM COMPANY (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0411625-A2 | Method to produce poly(arylene sulfide/sulfone) polymer | PHILLIPS PETROLEUM COMPANY (US) | 1991-02-06 | — | — | EP | disclosed |
| US-4880901-A | DICHLOROAROMATICS WITH SODIUM SULFIDE AND ONE TRIHALOAROMATIC, INJECTION MOLDING | PHILLIPS PETROLEUM COMPANY (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0323723-A2 | Process for producing poly (para-phenylene-sulfide) | Tosoh Corporation (JP) | 1989-07-12 | — | — | EP | disclosed |
| US-4740569-A | DIHALO BENZENE, SODIUM SULFIDE, ORGANIC AMIDE, ALKALI METAL CARBOXYLATE | PHILLIPS PETROLEUM COMPANY (US) | 1988-04-26 | — | — | US | disclosed |
| EP-0100551-B1 | ARYLENE SULFIDE TERPOLYMERS AND PROCESSES FOR MAKING THEM | PHILLIPS PETROLEUM COMPANY (US) | 1987-07-15 | — | — | EP | disclosed |
| US-4656231-A | Arylene sulfide polymerization; arylene sulfide polymer treated with aromatic compound having more than 2 halogen substituents; processed product thereof | PHILLIPS PETROLEUM COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0206000-A1 | (2,3)-Alpha-methylenepenam-3-carboxylic acids and derivatives thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1986-12-30 | — | — | EP | disclosed |
| EP-0100551-A2 | Arylene sulfide terpolymers and processes for making them | PHILLIPS PETROLEUM COMPANY (US) | 1984-02-15 | — | — | EP | disclosed |
| US-4350810-A | Preparation of branched chain arylene sulfide polymer | PHILLIPS PETROLEUM COMPANY (US) | 1982-09-21 | — | — | US | disclosed |
| US-4282347-A | AGING, RESISTANT FIBERS | PHILLIPS PETROLEUM COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4127713-A | FORM A DIHALOAROMATIC SULFONE, ALKALI METAL SULFIDE, AMIDE, SODIUM CARBOXYLATE AND WATER | PHILLIPS PETROLEUM COMPANY (US) | 1978-11-28 | — | — | US | disclosed |
| US-4116947-A | FROM P-DIHALOBENZENE, POLYHALO AROMATIC COMPOUND, ALKALI METAL SULFIDE, N-ALKYL LACTAM AND WATER | PHILLIPS PETROLEUM COMPANY (US) | 1978-09-26 | — | — | US | disclosed |