Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985336 | 0.90 | MAPK14 (0.45) | OPRD1PTGS2PTGS1KDM4EMEN1 | |
| SCHEMBL8985524 | 0.85 | MAPK14 (0.51) | OPRD1PTGS2PTGS1KDM4EMEN1 | |
| SCHEMBL8985469 | 0.85 | AURKA (0.47) | OPRD1PTGS2PTGS1KDM4EPLK4 | |
| SCHEMBL8985491 | 0.83 | PTGS2 (0.43) | PTGS2PTGS1KDM4EMEN1MAPT | |
| SCHEMBL8985459 | 0.82 | CYP1A2 (0.37) | PTGS2PTGS1KDM4EMEN1MAPT | |
| SCHEMBL8985319 | 0.79 | PTGS2 (0.34) | PTGS2PTGS1KDM4EMEN1MAPT | |
| SCHEMBL8985449 | 0.78 | OPRD1 (0.38) | OPRD1PTGS2PTGS1NPC1MAPK14 | |
| SCHEMBL8985226 | 0.75 | MAPK14 (0.47) | OPRD1PTGS2PTGS1MAPTNPC1 | |
| SCHEMBL8985252 | 0.74 | MAPK14 (0.44) | OPRD1PTGS2PTGS1MAPTMAPK14 | |
| SCHEMBL24035226 | 0.74 | MEN1 (0.49) | KDM4EMEN1MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |