Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985448 | 0.90 | OPRD1 (0.39) | MAPK14OPRD1PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8985524 | 0.86 | MAPK14 (0.51) | MAPK14OPRD1PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8985226 | 0.85 | MAPK14 (0.47) | MAPK14OPRD1PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8985491 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1ALDH1A1MEN1KMT2A | |
| SCHEMBL8985252 | 0.83 | MAPK14 (0.44) | MAPK14OPRD1PTGS2PTGS1EP300 | |
| SCHEMBL8985459 | 0.83 | CYP1A2 (0.37) | PTGS2PTGS1ALDH1A1MEN1KMT2A | |
| SCHEMBL8985319 | 0.80 | PTGS2 (0.34) | PTGS2PTGS1ALDH1A1MEN1KMT2A | |
| SCHEMBL8985419 | 0.78 | MAPK14 (0.52) | MAPK14OPRD1PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8985272 | 0.78 | MAPK14 (0.52) | MAPK14OPRD1PTGS2PTGS1ALDH1A1 | |
| SCHEMBL8985338 | 0.77 | MAPK14 (0.46) | MAPK14OPRD1PTGS2PTGS1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571810-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, COLLAGEN DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-11-05 | — | — | US | disclosed |
| EP-0593761-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |
| WO-1991019708-A1 | NEW THIOPHENE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-26 | — | — | WO | disclosed |