Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898805 | 1.00 | GRM5 (0.34) | GRM5CA9MAPK1NPSR1CYP1A2 | |
| SCHEMBL899483 | 0.92 | PTGS2 (0.36) | GRM5CA9CYP1A2CYP2C19P2RX7 | |
| SCHEMBL899322 | 0.83 | OPRD1 (0.35) | MAPK1NPSR1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL899220 | 0.79 | PDE4D (0.38) | MAPK1NPSR1CYP1A2CYP2C19P2RX7 | |
| SCHEMBL898781 | 0.78 | ROCK2 (0.41) | GRM5MAPK1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL898780 | 0.78 | ROCK2 (0.41) | GRM5MAPK1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL899436 | 0.77 | PDE4D (0.39) | MAPK1NPSR1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL899437 | 0.77 | PDE4D (0.39) | MAPK1NPSR1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL899582 | 0.77 | SMN1; SMN2 (0.42) | MAPK1NPSR1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL899584 | 0.77 | SMN1; SMN2 (0.42) | MAPK1NPSR1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | claimed |
| WO-2012040754-A2 | NOVEL THIAZOLAMINE DERIVATES AS DIFFERENTIATION ACCELERATORS | TECHNISCHE UNIVERSITÄT WIEN (AT) | 2012-04-05 | — | — | WO | disclosed |