Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564733 | 0.98 | HRH3 (0.32) | PTPN1HRH3HDAC1ALDH1A1LMNA | |
| SCHEMBL8988515 | 0.89 | HRH3 (0.36) | PTPN1HRH3HDAC1ALDH1A1LMNA | |
| SCHEMBL9564728 | 0.86 | HRH3 (0.33) | PTPN1HRH3HDAC1 | |
| SCHEMBL8988712 | 0.86 | ALDH1A1 (0.35) | PTPN1HRH3HDAC1ALDH1A1LMNA | |
| SCHEMBL9564737 | 0.85 | HRH3 (0.34) | PTPN1HRH3HDAC1ALDH1A1LMNA | |
| SCHEMBL8988493 | 0.83 | CYP4F2 (0.38) | PTPN1HRH3LMNAL3MBTL1 | |
| SCHEMBL9564731 | 0.83 | CASP1 (0.33) | PTPN1HRH3HDAC1 | |
| Hydrochloric Acid SCHEMBL8988806 | 0.82 | HRH3 (0.36) | PTPN1HRH3HDAC1LMNAL3MBTL1 | |
| SCHEMBL8988708 | 0.82 | MASP2 (0.32) | PTPN1HRH3HDAC1 | |
| SCHEMBL8988689 | 0.81 | ITGB3 (0.43) | PTPN1HRH3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5489693-A | ANTICOAGULANTS | DR. KARK THOMAE, GMBH (DE) | 1996-02-06 | — | — | US | disclosed |