SCHEMBL8991459

SCHEMBL8991459

CC(C)CCSC(C)(C)C

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.42
DRD2 P14416 1/20 0.42
HTR2A P28223 1/20 0.42
HTR7 P34969 1/20 0.42
CTSL P07711 1/20 0.36
CTSB P07858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8991382 0.97 HTR1A (0.40) HTR1ADRD2HTR2AHTR7CTSL
SCHEMBL9425488 0.78 HTR1A (0.39) HTR1ADRD2HTR2AHTR7
SCHEMBL15961176 0.78 HTR1A (0.39) HTR1ADRD2HTR2AHTR7
SCHEMBL23072536 0.76 HTR1A (0.37) HTR1ADRD2HTR2AHTR7
SCHEMBL12022838 0.76 CTSL (0.32) CTSLCTSB
SCHEMBL16135225 0.76 CTSL (0.32) CTSLCTSB
SCHEMBL3391323 0.73 HTR1A (0.56) HTR1ADRD2HTR2AHTR7
SCHEMBL355889 0.70 HTR1A (0.53) HTR1ADRD2HTR2AHTR7
SCHEMBL18963342 0.69 NOS1 (0.33) CTSLCTSB
SCHEMBL12139950 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240216290-A1 LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF RECODE THERAPEUTICS, INC. 2024-07-04 US disclosed
US-20240216515-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2024-07-04 US disclosed
US-12024486-B2 Lipocationic dendrimers and uses thereof THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-07-02 US disclosed
US-20240207178-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-06-27 US disclosed
CN-117924548-A Catalyst component for olefin polymerization, preparation method, catalyst system and olefin polymerization method 中国石油化工股份有限公司 2024-04-26 CN disclosed
US-20240025848-A1 LIPOCATIONIC DENDRIMERS AND USES THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-01-25 US disclosed
US-11858884-B2 Compositions and methods for modulating gene or gene product in cells THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-01-02 US disclosed
US-20230302138-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS RECODE THERAPEUTICS, INC. 2023-09-28 US disclosed
US-20230293429-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS RECODE THERAPEUTICS, INC. 2023-09-21 US disclosed
US-9650456-B2 Process for producing polydienes BRIDGESTONE CORPORATION (JP) 2017-05-16 US disclosed
EP-2825574-B1 PROCESS FOR PRODUCING POLYDIENES BRIDGESTONE CORP (JP) 2016-02-24 EP disclosed
US-20150031845-A1 Process For Producing Polydienes BRIDGESTONE CORPORATION (JP) 2015-01-29 US disclosed
EP-2825574-A1 PROCESS FOR PRODUCING POLYDIENES Bridgestone Corporation (JP) 2015-01-21 EP disclosed
WO-2013138270-A1 PROCESS FOR PRODUCING POLYDIENES BRIDGESTSONE CORPORATION (JP) 2013-09-19 WO disclosed
US-7553842-B2 Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases ARRAY BIOPHARMA INC. (US) 2009-06-30 US disclosed
US-5567849-A Borane-sulfide hydroboration agents ALDRICH CHEMICAL COMPANY, INC. (US) 1996-10-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240025848-A1 LIPOCATIONIC DENDRIMERS AND USES THEREOF LIPA, LIPC, TLR9 HTR1A 3967/4885DRD2 2530/4885HTR2A 3961/4885
US-20230302138-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS CHMP4B, LIPA, NPC1L1 HTR1A 3916/4885DRD2 4087/4885HTR2A 4122/4885
US-12024486-B2 Lipocationic dendrimers and uses thereof LIPA, LIPC, TLR9 HTR1A 3967/4885DRD2 2530/4885HTR2A 3961/4885
US-20240207178-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS CHMP4B, LIPA, NPC1L1 HTR1A 3916/4885DRD2 4087/4885HTR2A 4122/4885
US-20240216290-A1 LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF LIPA, NPC1L1, NPC1 HTR1A 4697/4885DRD2 3696/4885HTR2A 4680/4885
US-20240216515-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS PNLIP, LIPA, PHOSPHO1 HTR1A 4509/4885DRD2 4343/4885HTR2A 4458/4885
US-20230293429-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS CHMP4B, LIPA, NPC1L1 HTR1A 3916/4885DRD2 4087/4885HTR2A 4122/4885
US-11858884-B2 Compositions and methods for modulating gene or gene product in cells DGKB, DGKG, DGKA HTR1A 4547/4885DRD2 3237/4885HTR2A 4045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.