SCHEMBL8991901

SCHEMBL8991901

O=C(O)CNCc1ccc(Cl)cc1

nearest known ligand 0.65

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.65
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
FFAR1 O14842 1/20 0.56
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
GAA P10253 2/20 0.51
CHRM2 P08172 1/20 0.50
FOLH1 Q04609 1/20 0.49
KDM4E B2RXH2 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8338352 0.82 CYP2C9 (0.61) ALDH1A1MEN1KMT2ACYP2C9CYP2C19
SCHEMBL27922741 0.82 CHRM2 (0.62) ALDH1A1MEN1KMT2AFFAR1CHRM2
SCHEMBL287925 0.82 CA2 (0.54) ALDH1A1
SCHEMBL156664 0.81 MEN1 (0.56) ALDH1A1MEN1KMT2AFFAR1GAA
SCHEMBL8780612 0.81 LMNA (0.55) ALDH1A1FFAR1CYP2C19GAASMN1; SMN2
SCHEMBL31148844 0.81 ALDH1A1 (0.56) ALDH1A1MEN1KMT2ACYP2C9CYP2C19
SCHEMBL23105604 0.80 LMNA (0.52) ALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL1202552 0.80 HTT (0.61) ALDH1A1CYP2C9CYP2C19CHRM2FOLH1
SCHEMBL18487413 0.80 FOLH1 (0.49) ALDH1A1FOLH1
SCHEMBL841278 0.80 L3MBTL1 (0.50) MEN1KMT2ACYP2C19FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3328877-B1 PEPTOID THE UNIV OF DURHAM (GB) 2022-08-24 EP claimed
US-20180201647-A1 Peptoid THE UNIVERSITY OF DURHAM (GB) 2018-07-19 US claimed
US-20130165446-A1 BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE HORIKOSHI, HIROYOSHI (CA) 2013-06-27 US claimed
EP-2581373-A1 BENZO- OR PYRIDO-IMIDAZOLE DERIVATIVE Fujita, Takashi (JP) 2013-04-17 EP claimed
CN-118772034-A Preparation process of 2-p-chlorophenyl-5- (trifluoromethyl) pyrrole-3-nitrile 山东亿嘉农化有限公司 2024-10-15 CN disclosed
CN-118772034-A Preparation process of 2-p-chlorophenyl-5- (trifluoromethyl) pyrrole-3-nitrile 山东亿嘉农化有限公司 2024-10-15 CN disclosed
US-20240327461-A1 APELIN POLYPEPTIDES AMGEN INC. (US) 2024-10-03 US disclosed
US-11807693-B2 Apelin polypeptides AMGEN INC. (US) 2023-11-07 US disclosed
EP-4257152-A2 APELIN POLYPEPTIDES Amgen Inc. (US) 2023-10-11 EP disclosed
EP-3674314-B1 APELIN POLYPEPTIDES AMGEN INC (US) 2023-05-03 EP disclosed
CN-111269134-B Preparation method of phenylglycine and derivatives thereof 九江中星医药化工有限公司 2022-09-20 CN disclosed
EP-3328877-B1 PEPTOID THE UNIV OF DURHAM (GB) 2022-08-24 EP disclosed
US-20130165446-A1 BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE HORIKOSHI, HIROYOSHI (CA) 2013-06-27 US disclosed
EP-2581373-A1 BENZO- OR PYRIDO-IMIDAZOLE DERIVATIVE Fujita, Takashi (JP) 2013-04-17 EP disclosed
US-7271176-B2 Chemokine receptor antagonists and methods of use thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2007-09-18 US disclosed
US-5527882-A BRADYKININ THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-06-18 US disclosed
CN-1076690-A SULFONAMIDOCARBOXAMIDES HOFFMANN LA ROCHE (CH) 1993-09-29 CN disclosed
EP-0148752-B1 PROTEASE INHIBITORS G.D. Searle & Co. (US) 1989-06-21 EP disclosed
US-4551279-A Protease inhibitors G. D. SEARLE & CO. (US) 1985-11-05 US disclosed
EP-0148752-A2 Protease inhibitors G.D. Searle & Co. (US) 1985-07-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180201647-A1 Peptoid ARG1, ARGLU1, QPCT ALDH1A1 4876/4885MEN1 988/4885KMT2A 1117/4885
US-20130165446-A1 BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE PPARG, PPARA, PPARD ALDH1A1 1612/4885MEN1 4822/4885KMT2A 1996/4885
US-11807693-B2 Apelin polypeptides APLNR, FABP3, AP3B1 ALDH1A1 3602/4885MEN1 1617/4885KMT2A 4510/4885
US-20240327461-A1 APELIN POLYPEPTIDES APLNR, FABP3, AP3B1 ALDH1A1 3602/4885MEN1 1617/4885KMT2A 4510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.