Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992845 | 0.90 | FYN (0.40) | DHFRHSP90AA1HSP90AB1HCAR2ENPP1 | |
| SCHEMBL8992904 | 0.88 | GPR119 (0.39) | HCAR2ENPP1EGFRMEN1KMT2A | |
| SCHEMBL8992950 | 0.87 | LTA4H (0.43) | DHFRHSP90AA1HSP90AB1HCAR2ENPP1 | |
| SCHEMBL8993124 | 0.87 | GPR119 (0.37) | MEN1KMT2AALDH1A1TSHRNPC1 | |
| SCHEMBL8993106 | 0.86 | DHFR (0.40) | DHFRHCAR2ENPP1TGFBR2GPR52 | |
| SCHEMBL8993183 | 0.83 | FYN (0.40) | HCAR2EGFRMEN1KMT2AALDH1A1 | |
| SCHEMBL8993019 | 0.83 | BRS3 (0.47) | HCAR2GPR52ALDH1A1NPC1MAPT | |
| SCHEMBL9214289 | 0.82 | KDR (0.50) | ABL1EGFRCDK1SRCABL2 | |
| SCHEMBL8992894 | 0.80 | MAPT (0.40) | MEN1KMT2AALDH1A1LMNACYP1A2 | |
| SCHEMBL8992897 | 0.80 | FYN (0.41) | MEN1KMT2AALDH1A1LMNAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |