Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B known ✓ | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C known ✓ | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D known ✓ | Q08499 | 2/20 | 0.40 |
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.37 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304771 | 0.83 | SRC (0.57) | SRCALDH1A1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL10386606 | 0.80 | KMT2A (0.56) | SRCALDH1A1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL22014067 | 0.79 | TSHR (0.56) | SRCALDH1A1KMT2ACYP2C19LMNA | |
| SCHEMBL10909571 | 0.79 | KMT2A (0.58) | SRCALDH1A1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL6677049 | 0.79 | TSHR (0.56) | SRCALDH1A1KMT2ACYP2C19LMNA | |
| SCHEMBL22014331 | 0.79 | TSHR (0.56) | SRCALDH1A1KMT2ACYP2C19LMNA | |
| SCHEMBL6673825 | 0.77 | TSHR (0.55) | SRCALDH1A1KMT2ACYP2C19LMNA | |
| SCHEMBL8814382 | 0.77 | SRC (0.50) | SRCALDH1A1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL14955287 | 0.77 | SRC (0.57) | SRCALDH1A1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL14955046 | 0.77 | SRC (0.57) | SRCALDH1A1KMT2ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482777-A | CROSSLINKED WITH RESIN CONTAINING EPOXY GROUPS, ADDITIONAL BINDER CONTAINING ANIONIC OR CATIONIC GROUPS | NIPPON ZEON CO., LTD. (JP) | 1996-01-09 | — | — | US | disclosed |
| EP-0435264-B1 | Binders for powder and magnetic recording media using same | NIPPON ZEON CO (JP) | 1995-06-28 | — | — | EP | disclosed |
| EP-0435264-A1 | Binders for powder and magnetic recording media using same | NIPPON ZEON CO., LTD. (JP) | 1991-07-03 | — | — | EP | disclosed |