Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 5/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11791322 | 0.86 | CALM1 (0.55) | CALM1AKR1B1CYP19A1ALDH1A1CA2 | |
| SCHEMBL8993364 | 0.85 | LTA4H (0.65) | CALM1LTA4HALDH1A1SAE1UBA2 | |
| SCHEMBL8993038 | 0.83 | MTNR1A (0.56) | LTA4HMTNR1AMTNR1B | |
| SCHEMBL65276 | 0.83 | ALDH1A1 (0.58) | CALM1AKR1B1CYP19A1ALDH1A1 | |
| SCHEMBL5252553 | 0.82 | ALDH1A1 (0.65) | CALM1AKR1B1LTA4HCYP19A1ALDH1A1 | |
| SCHEMBL19352719 | 0.82 | CALM1 (0.56) | CALM1AKR1B1LTA4HCYP19A1ALDH1A1 | |
| SCHEMBL28123040 | 0.81 | ALDH1A1 (0.55) | CALM1AKR1B1CYP19A1ALDH1A1 | |
| SCHEMBL8993062 | 0.80 | CALM1 (0.54) | CALM1AKR1B1LTA4HCYP19A1ALDH1A1 | |
| SCHEMBL26784208 | 0.80 | ABL1 (0.62) | AKR1B1ERN1MTNR1AMTNR1B | |
| SCHEMBL11810459 | 0.79 | LTA4H (0.69) | CALM1LTA4HCYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |