Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | FKBP1B | P68106 | 1/20 | 0.34 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992825 | 0.90 | TACR1 (0.37) | TACR1NPC1RAB9AICAM1SELE | |
| SCHEMBL8992789 | 0.90 | TACR1 (0.40) | TACR1NPC1RAB9APOLBFFAR1 | |
| SCHEMBL8632096 | 0.80 | ALDH1A1 (0.50) | TACR1NPC1RAB9APOLBLMNA | |
| SCHEMBL8993128 | 0.78 | DHFR (0.46) | TACR1NPC1RAB9AICAM1SELE | |
| SCHEMBL8992790 | 0.78 | TACR1 (0.43) | TACR1ICAM1SELECREBBPSLC6A3 | |
| SCHEMBL18410184 | 0.74 | ICAM1 (0.40) | NPC1RAB9AICAM1SELECREBBP | |
| SCHEMBL18410186 | 0.73 | NPC1 (0.40) | NPC1RAB9APOLBICAM1SELE | |
| SCHEMBL27343854 | 0.73 | CREBBP (0.38) | TACR1ICAM1SELELMNACREBBP | |
| SCHEMBL8321396 | 0.72 | NPC1 (0.50) | TACR1NPC1RAB9AICAM1SELE | |
| SCHEMBL8992916 | 0.72 | DHFR (0.46) | TACR1NPC1RAB9APOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |