Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.62 |
| ▸ | ABL1 | P00519 | 4/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.56 |
| ▸ | BCR | P11274 | 4/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19428392 | 0.84 | TTR (0.65) | ESR1MEN1KMT2ATTRERN1 | |
| SCHEMBL18855325 | 0.81 | TTR (0.61) | ESR1MEN1KMT2ATTRERN1 | |
| SCHEMBL7929549 | 0.80 | CRHBP (0.54) | ESR1ESR2MEN1KMT2ATTR | |
| SCHEMBL13590994 | 0.78 | ALOX5 (0.62) | ESR1ABL1ABCB1BCRESR2 | |
| SCHEMBL8994752 | 0.78 | SNCA (0.47) | ESR1MEN1KMT2ATTRALOX5 | |
| SCHEMBL24617945 | 0.78 | ESR1 (1.00) | ESR1ABL1ABCB1BCRESR2 | |
| SCHEMBL187833 | 0.78 | ESR1 (1.00) | ESR1ABL1ABCB1BCRESR2 | |
| SCHEMBL920655 | 0.78 | ESR1 (1.00) | ESR1ABL1ABCB1BCRESR2 | |
| SCHEMBL6723587 | 0.76 | TTR (0.63) | MEN1KMT2ATTRMMP3 | |
| SCHEMBL8773702 | 0.76 | RXRA (0.60) | BCL2L1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585404-A | ANTIARRHYTHMIA AGENT | KARO BIO AB (SE) | 1996-12-17 | — | — | US | disclosed |
| US-5567728-A | BENZOYL BENZOFURAN DERIVATIVES USED TO PREVENT OR TREAT CARDIAC ARRHYTHMIA | KAROBIO AKTIEBOLAG (SE) | 1996-10-22 | — | — | US | disclosed |
| EP-0584186-B1 | RECEPTOR LIGANDS | KAROBIO AB (SE) | 1996-08-21 | — | — | EP | disclosed |
| EP-0584186-A1 | RECEPTOR LIGANDS. | KAROBIO AB (SE) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | disclosed |