Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995027 | 0.86 | NPC1 (0.54) | MAPTLMNAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL8994960 | 0.82 | LMNA (0.50) | MAPTLMNAL3MBTL1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL8995003 | 0.81 | PRSS1 (0.56) | MAPTLMNAL3MBTL1HRH3MEN1 | |
| Hydrochloric Acid SCHEMBL8994944 | 0.75 | PRSS1 (0.68) | HRH3CHRM2ADRA2ASLC6A3OPRM1 | |
| SCHEMBL8995101 | 0.74 | PDE10A (0.51) | NPC1RAB9APOLBTSHR | |
| SCHEMBL11630789 | 0.73 | LMNA (0.48) | MAPTLMNAL3MBTL1ALDH1A1MEN1 | |
| SCHEMBL9307381 | 0.73 | LMNA (0.67) | MAPTLMNAL3MBTL1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9547438 | 0.73 | LMNA (0.53) | MAPTLMNAL3MBTL1ALDH1A1HRH3 | |
| SCHEMBL8994948 | 0.73 | LTB4R (0.59) | — | |
| SCHEMBL8994945 | 0.72 | LTB4R (0.55) | L3MBTL1HRH3MEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |